Research Projects and Accomplishments
- Morris Animal Foundation Study ID: D17CA-049: Evaluating a new treatment for a deadly blood disorder in dogs. Scientific Title: Inhibiting Complement Activation: A Novel Therapeutic Strategy for Canine Immune-mediated Hemolytic Anemia, ($3000), Erica L. Behling-Kelly, DVM, PhD, Cornell University
- Morris Animal Foundation Study ID: D17CA-059: Curbing tumor growth and chemotherapy resistance in canine hemangiosarcoma. Scientific Title: Targeting Beta-AR Signaling to Arrest Hemangiosarcoma Progression and Overcome Chemoresistance, ($3000), Erin B; Dickerson, PhD, University of Minnesota
- Assisted the Clumber Spaniel Club of America with organizing and funding and running the Clumber Spaniel International Symposium, including a Breeders Round Table discussion, at the CSCA National Specialty Show.
- Clumber Spaniel Health Foundation Grant Application: “Genetics of IMHA in Clumber Spaniels”, ($4667), Investigator Steven Friedenberg, MBA, DVM, PhD, DACVECC, University of Minnesota
- Morris Animal Foundation Study ID: D16CA-081: “Improving Outcomes for Dogs with Acute Spinal Cord Injuries”, ($3000), Investigator Natasha J. Olby, VetMB, PhD, North Carolina State University
- Canine Health Foundation Grant 02217: “A Novel Mechanism to Regulate the Growth of Canine Hemangiosarcoma”, ($3000), Investigator Dr. Erin B. Dickerson, PhD, University of Minnesota
- Canine Health Foundation Grant 02287: “Enhanced Testing for the Diagnosis of Bartonellosis in Dogs”, ($250), Investigator Dr. Edward B Breitschwerdt, DVM; North Carolina State University
- The Clumber Spaniel DNA Bank was successfully transferred from VARI to the NIH.
- CSHF Sponsored Workshop at the 2015 CSCA National Specialty featuring a Fit Paws exercise equipment program along with instruction from physical therapist Giuliana Lerch.
- As a Millennium contributor to the Canine Health Foundation the CSHF had the opportunity to send a delegate, Board Member Roe Froman, DVM, to the AKC Parent Club Health Conference. CSHF Board member Janice Friis attended the conference as a representative of the Clumber Spaniel Club of America, and Dr. Larry Schwartz who is on the CSHF Scientific Advisory Committee also attended.
- Canine Health Foundation Grant 01759: “Disrupting the Differentiation of Cancer Stem Cells to Prevent the Spread of Hemangiosarcoma”, ($3,000), Investigator Dr. Jaime F Modiano, VMD PhD; University of Minnesota
- Morris Animal Foundation Grant D14CA0-047: “Testing Strategies to Treat Drug-Resistant Hemangiosarcoma,” ($5,000), Investigator Dr. Erin B. Dickerson, University of Minnesota
- Canine Health Foundation Grant 01889-G: “Innovations in Prevention, Diagnosis, and Treatment of Cancer”, ($3,000), Investigator Dr. Jaime F Modiano, VMD PhD; University of Minnesota
- Canine Health Foundation Grant 02143-A: “Development of a Novel Treatment for Intervertebral Disc Disease” ($5,000), Investigator Dr. Gordon S. Mitchell; University of Wisconsin
- Canine Health Foundation Grant 01828: “Mapping Genetic Risk Factors for Canine Hip Dysplasia”, ($5,000), Investigator Dr. Antti Iivanainen, DVM, PhD, University of Helsinki and the Folkhalsan Institute of Genetics
- Canine Health Foundation Grant 01988: “Identification of a Safe Storage Time for Canine Blood Used in the Treatment of Anemia”, ($3000), Investigator Dr. Mary Beth Callan, V.M.D., University of Pennsylvania
- The CSHF Board initiated a “Clumber Spaniel Longevity Study” to help determine the average or median age that Clumbers live. The study also investigated the cause of death of Clumbers. This Longevity Study is an ongoing investigation and you can update information on your dog as it becomes available: http://bit.ly/clumberlongevity. The data is confidential and only summary data will be reported. To update information related to your dog, please contact Kim Daboo at email@example.com.
- Morris Animal Foundation Study ID D12CA-06: “Developing Stem Cells to Treat Spinal Cord Injuries”, Investigator Dr. Jose Cibelli, Michigan State University
- Morris Animal Foundation Study ID D12CA-313,” Evaluating a New Cell Therapy for Osteoarthritis in Dogs”, Investigator Dr. Thomas G. Koch, University of Guelph, Canada
- Morris Animal Foundation Study ID D13CA-024, “Assessing Recovery After Spinal Cord Injury”, Investigator Dr. Sarah A. Moore, The Ohio State University
- AKC Canine Health Foundation Study ID 01787: “Clinical Advancement of a Cancer Vaccine in Dogs”, Investigator Dr. Nicola J Mason, BVetMed, PhD, University of Pennsylvania
- Morris Animal Foundation Study D10CA-501: “MADGiC: Making Advanced Discoveries in Golden Cancers”, ($3000), Investigator Dr. Jaime F. Modiano, North Carolina State University
- Morris Animal Foundation Study D10CA-040: “Treating Canine Paralysis with Stem Cells”, ($3000), Investigator Natasha J. Olby, VetMB, PhD, North Carolina State University
- Morris Animal Foundation Study D08CA-050: “Evaluating Drugs to Treat Hemangiosarcoma”, ($3000), Dr. Stuart C. Helfand, Oregon State University
- IMHA: The CSHF continues to support Dr. Lorna Kennedy’s studies into Immune Mediated Hemolytic Anemia. Dr. Kennedy is at the Centre for Integrated Genomic Medical Research at the University of Manchester, UK. We provide partial funding as well as DNA for this project. Dr. Kennedy’s research on Clumber DNA to date shows a marked lack of variation in important immune system components, which may predispose Clumbers to this condition.
- Hemangiosarcoma: The CSHF is supporting a National Institutes of Health Go! Grant received by the Van Andel Research Institute via the contribution of DNA from Clumbers affected with hemangiosarcoma. VARI is studying the biochemical pathways and genetic markers of this disease, to develop earlier diagnostics, better treatments and perhaps DNA tests to enable breeders to work around this deadly cancer.
- Intervertebral Disc Disease: Drs. Mark Neff and Nick Duesbery of the Van Andel Research Institute are investigating intervertebral disc disease in Clumbers. The CSHF is supporting this work both through financial support and provision of DNA samples.
- Clumber Genome: The CSHF has provided DNA from a Clumber spaniel to the T-Gen and the complete genome has been mapped.
- Hemangiosarcoma (HSA): DNA from affected and unaffected Clumbers is part of a federally funded research effort based at the Van Andel Research Institute in Michigan and TGen in Arizona. Hundreds of DNA samples from several breeds of dogs are being evaluated to assess how the DNA of dogs who develop HSA varies from those dogs that do not. The research goal is to develop earlier diagnostic methods, improved therapies and perhaps even DNA tests. Drs. Nick Duesbery and Mark Neff from VARI are two of the Primary Investigators for the HSA/canine cancer research project.
- Immune Mediated Hemolytic Anemia (IMHA): IMHA is deadly disease which affects Clumbers as well as many other breeds. IMHA causes a sudden onset, life-threatening anemia, when the dog’s immune system starts to attack its own red blood cells. Dr. Lorna Kennedy at the University of Manchester, UK, continues to investigate how and why the immune system goes awry in affected dogs. The CSHF supported her research in 2010 via a contribution to the CSCA Donor Advised Fund at the Canine Health Foundation
- Intervertebral Disc Disease (IVDD): Drs. Mark Neff and Nick Duesbery at the Van Andel Research Institute are investigating this condition in Clumbers. Forty DNA samples were sent to TGen in Phoenix for SNP analysis in December 2010.
- Immune Mediated Hemolytic Anemia (IMHA): Dr. Lorna Kennedy at the University of Manchester, UK. We provide DNA and financial support.
- Hemangiosarcoma (HSA): Van Andel Research Institute in Michigan. We provide DNA. This research is funded via an NIH/National Cancer Institute million-dollar grant.
- Intervertebral Disc Disease (IVDD): Drs. Mark Neff and Nick Duesbery at the Van Andel Research Institute. The CSHF provides financial support and the CSCA DNA bank provides DNA.
- Received 501(c)(3) status from the Internal Revenue Service, making all contributions tax deductible to the extent allowed by law in the US.
- Launched the Clumber Spaniel Health Foundation website (Diane McGrew, webmaster) at www.clumberhealth.org.
- Funded, in cooperation with the Clumber Spaniel Club of America, an Associate Sponsorship of the AKC CHF Canine Cancer Conference.
- Continued to support research project into Immune Mediated Hemolytic Anemia.
- Served as a member of the International Health Committee.
The Clumber Spaniel Health Foundation was formally created 3 April 2007. During the remainder of the year the CSHF we have:
- Approved its Articles of Incorporation and By-Laws.
- Signed a Memorandum of Understanding with the CSCA concerning stewardship of the Clumber Spaniel DNA Bank.
- Applied for 501(c)(3) status.
- Incorporated the Piper Fund within the foundation at the request of its founders, Kim and Cyrus Daboo.
- Managed the DNA data base at the University of Missouri.
- Supported its first grant to an IMHA research project (Dr. Lorna Kennedy) at the University of Manchester in the UK. Provided DNA and $3000.
- Funded the University of Missouri to digitalize the Clumber DNA Bank to simplify finding research samples.
- Participated in the Canine Phenome Project as one of the beta test breeds, at no cost to the foundation.
OnGoing Projects and Activities
- Health Seminars: The CSHF will continue to provide health seminars at the National Specialty show whenever possible. These include:
- Keynote speaker at the CSCA 2017 International Symposium, Dr. Heidi Parker from the National Institute of Health, who spoke on canine genetics
- Dr. Margaret Root from the University of Minnesota who spoke on prostate issues at the 2013 National Specialty
- Dr. Jon Levine from Texas A&M speaking on IVDD at the 2012 National Specialty
- Dr. Mark Neff, renowned canine geneticist at 2010 National Specialty
- Dr. Nick Duesbery addressed progress in hemangiosarcoma research at the 2009 Clumber National Specialty
- PDP1 Data Base: The Clumber Spaniel Health Foundation continues to maintain an international PDP1 database for Clumber and Sussex Spaniels. The PDP1 list is housed on the CSHF website.
- Piper Fund: The Piper Fund, established by Cyrus and Kim Daboo in loving memory of their Clumber Piper, continues to fund rebates to owners of Clumbers who have their dogs necropsied after death, and who provide a copy of the necropsy report to enable better understanding of diseases in our dogs.
- Clumber Spaniel DNA Bank: The Foundation also manages the CSCA DNA bank, and sponsors collection clinics to continually build this important health resource.